| Identification | Back Directory | [Name]
(R)-(+)-SKF-38393 hydrochloride | [CAS]
81702-42-3 | [Synonyms]
R-SKF-38393A HCl
R(+)-SKF-38393 HYDROCHLORIDE
RSKF38393A HCl,R SKF 38393A HCl | [Molecular Formula]
C16H17NO2.ClH | [MDL Number]
MFCD00055189 | [MOL File]
81702-42-3.mol | [Molecular Weight]
291.776 |
| Chemical Properties | Back Directory | [Melting point ]
244-246 °C | [storage temp. ]
-20°C | [solubility ]
0.1 M HCl: soluble1.2mg/mL | [form ]
solid | [color ]
off-white to light tan | [Optical Rotation]
[α]22/D +16.1°, c = 1.2 in methanol(lit.) | [Water Solubility ]
water: 100mM |
| Hazard Information | Back Directory | [Uses]
(R)-(+)-SKF-38393 hydrochloride has been used as a D1 dopamine receptor agonist to study its effect on the sleep-wake pattern of macaques rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). | [Uses]
(R)-(+)-SKF-38393 Hydrochloride is the active enantiomer of (±)-SKF-38393, a D1 dopamine receptor agonist. | [Biochem/physiol Actions]
(R)-(+)-SKF-38393 hydrochloride is a D1 dopamine receptor agonist and an active enantiomer of (±)-SKF-38393. It enhances pertussis toxin-insensitive and protein kinase A-mediated glutamate release in the hippocampal neurons. SKF-38393, a?benzazepine derivative, exhibits anorectic effects. |
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