| Identification | Back Directory | [Name]
6,9ALPHA-METHYLENE-9BETA-METHYL-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, CALCIUM SALT | [CAS]
81703-55-1 | [Synonyms]
U-61431F
CIPROSTENE CALCIUM
CIPROSTENE CALCIUM SALT
9-beta-methylcarbacyclin
WKRNCYQUQFBOCZ-FCIOBEBZSA-M
pentalenylidene)-,calciumsalt(2:1),(3as-(2z,3a-alpha,5-beta,6-alpha(1e,3r*
5-(hexahydro-5-hydroxy-6-(3-hydroxy-1-octenyl)-3a-methyl-2(1h)-pentanoicaci
6,9ALPHA-METHYLENE-9BETA-METHYL-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, CALCIUM SALT | [Molecular Formula]
C22H38CaO4 | [MDL Number]
MFCD01632742 | [MOL File]
81703-55-1.mol | [Molecular Weight]
406.62 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: > 25 mg/ml; DMSO: > 16.8 mg/ml; ethanol: > 34 mg/ml; PBS pH 7.2: > 0.29 μg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
Ciprostene is the 9β-methyl analog of carbaprostacyclin and a stable analog of PGI2. Ciprostene exhibits biological activity similar to PGI2, but is 30-fold less potent. In patas monkeys, ciprostene induces hypotension and causes tachycardia when administered at a dose of 0.16 μg/kg/min. In addition, ciprostene inhibits ADP-induced platelet aggregation ex vivo and in vitro with ID50 values of 9.1 μg/kg/min and 60 ng/ml, respectively. | [Uses]
Platelet aggregation inhibitor. | [storage]
Store at -20°C | [References]
[1] G. ALLAN. The cardiovascular and platelet actions of 9β-methyl carbacyclin (ciprostene), a chemically stable analogue of prostacyclin, in the dog and monkey[J]. British Journal of Pharmacology, 1985, 85 2: 547-555. DOI: 10.1111/j.1476-5381.1985.tb08892.x
[2] PAUL A. ARISTOFF Allen W H Paul D Johnson. Synthesis of 9-substituted carbacyclin analogs[J]. The Journal of Organic Chemistry, 1983, 48 26: 5341-5348. DOI: 10.1021/jo00174a035 |
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