| Identification | Back Directory | [Name]
CAFESTOL ACETATE | [CAS]
81760-48-7 | [Synonyms]
CAFESTOL ACETATE
5a,8-Methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol,3b,4,5,6,7,8,9,10,10a,10b,11,12-dodecahydro-7-hydroxy-10b-methyl-, 7-acetate,(3bS,5aS,7R,8R,10aR,10bS)- | [Molecular Formula]
C22H30O4 | [MDL Number]
MFCD00133152 | [MOL File]
81760-48-7.mol | [Molecular Weight]
358.47 |
| Chemical Properties | Back Directory | [Melting point ]
163～165℃ | [Boiling point ]
474.6±45.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [form ]
powder | [pka]
14.17±0.40(Predicted) | [color ]
white to off-white |
| Hazard Information | Back Directory | [Uses]
Cafestol acetate is a glutathione S-transferase inducer. | [Biological Activity]
Cafestol is a coffee-specific diterpene. It has anti-carcinogenic and anti-inflammatory activities. Cafestol stimulates apoptosis in cells associated with colorectal and renal cancer (Caki cells). It is used to study mechanisms of anti-oxidation related to hydrogen peroxide induced oxidative stress and DNA damage. Cafestol increases the level of glutathione (GSH)by stimulating γ-glutamylcysteine synthetase. It acts as a chemopreventive agent by inducing cytochrome P-450. |
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