| Identification | Back Directory | [Name]
2-[2-(5-bromofuran-2-yl)-4-oxochromen-3-yl]oxyacetamide | [CAS]
819827-50-4 | [Synonyms]
CB7993113
2-[2-(5-bromofuran-2-yl)-4-oxochromen-3-yl]oxyacetamide
Acetamide, 2-[[2-(5-bromo-2-furanyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]- | [Molecular Formula]
C15H10BrNO5 | [MOL File]
819827-50-4.mol | [Molecular Weight]
364.15 |
| Chemical Properties | Back Directory | [Boiling point ]
572.9±50.0 °C(Predicted) | [density ]
1.72±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
15.30±0.40(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
CB7993113 is a potent AHR antagonist, with an IC50 of 0.33 μM. CB7993113 directly binds AHR protein and blocks AHR nuclear translocation. CB7993113 inhibits polycyclic aromatic hydrocarbon (PAH)- and TCDD-induced reporter activity by 75% and 90% respectively[1]. | [in vivo]
CB7993113 effectively blocks acute, 50 mg/kg DMBA-induced hepatic CYP1A1 induction and bone marrow toxicity in vivo[1].
| [References]
[1] Parks AJ, et al. In silico identification of an aryl hydrocarbon receptor antagonist with biological activity in vitro and in vivo. Mol Pharmacol. 2014 Nov;86(5):593-608. DOI:10.1124/mol.114.093369 |
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| Company Name: |
OTAVA chemicals
|
| Tel: |
416 305 9979 (Canada) |
| Website: |
www.otavachemicals.com |
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