| Identification | Back Directory | [Name]
DOTA-mono-NHS-tris(t-Bu ester)(B-270) | [CAS]
819869-77-7 | [Synonyms]
DOTA-(COOt-Bu)3-NHS
DOTA-tris-tBu-ester NHS
DOTA tris(tBu)ester NHS ester
DOTA-Mono-NHS-tris(t-Bu ester)
DOTA-mono-NHS-tris(t-Butyl ester)
DOTA-mono-NHS-tris(t-Bu ester)(B-270)
2-[1, 4, 7, 10-Tetraazacyclododecane-4, 7, 10-tris(t-butyl acetate)I-pentanedioic acid-1-t-butyl ester
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 4,7,10-tris(1,1-dimethylethyl) 1-(2,5-dioxo-1-pyrrolidinyl) ester
Tri-tert-butyl 2,2'',2''''-(10-(2-((2,5-dioxopyrrolidin-1-yl)oxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate
1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 10-[2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl]-, tris(1,1-diMethylethyl) ester | [Molecular Formula]
C32H55N5O10 | [MOL File]
819869-77-7.mol | [Molecular Weight]
669.81 |
| Chemical Properties | Back Directory | [Boiling point ]
686.8±65.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C, protect from light | [solubility ]
DMSO, DMF, acetonitrile | [form ]
Solid | [pka]
5.49±0.20(Predicted) | [color ]
White to off-white | [Appearance]
white solid | [InChIKey]
XIICJKXKEDCZEE-UHFFFAOYSA-N | [SMILES]
N1(CC(ON2C(=O)CCC2=O)=O)CCN(CC(OC(C)(C)C)=O)CCN(CC(OC(C)(C)C)=O)CCN(CC(OC(C)(C)C)=O)CC1 |
| Hazard Information | Back Directory | [Description]
DOTA (dodecane tetraacetic acid, also known as tetraxetan) is a complexing agent, especially for lanthanide ions. DOTA-NHS ester is a bifunctional linker containing chelating and N-hydroxysuccinimide (NHS) ester groups for conjugation with amine-containing biomolecules.
DOTA-NHS ester can be used to label radiotherapeutic agents or imaging probes and detect labeled tumors with PET, SPECT, and CT methods. | [Uses]
DOTA-tris(tBu)ester NHS ester is a derivative of DOTA for the labeling of peptides and antibodies[1]. | [storage]
-20°C, protect from light | [References]
[1] W?ngler C, et, al. Improved syntheses and applicability of different DOTA building blocks for multiply derivatized scaffolds. Bioorg Med Chem. 2008 Mar 1; 16(5): 2606-16. DOI:10.1016/j.bmc.2007.11.044 |
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| Company Name: |
Bide Pharmatech Ltd. Gold
|
| Tel: |
400-400-164-7117 18317119277 |
| Website: |
www.bidepharm.com |
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