| Identification | Back Directory | [Name]
KHELLIN | [CAS]
82-02-0 | [Synonyms]
eskel
keloid
norkel
KHELIN
KHELLIN
kelamin
kelicor
chellin
ammivin
chellina
kalangin
khelfren
khelisem
rykellin
khelloyd
lynamine
VISNAGIN
VISAMMIN
kellosal
viscardan
khelangin
kelicorin
amikellin
ammipuran
benecardin
amicardine
khellamine
khellanals
medekellin
methafrone
visnagalin
vasokellina
gynokhellan
ammispasmin
ammivisnagen
simeskellina
cardio-khellin
KHELLIN(VISAMMIN)(P)
KHELLIN LIGHT YELLOW CRYSTALS
5,8-dimethoxy-2-methyl-6,7-furanochromone
5,8-dimethoxy-2-methyl-4’,5’-furo-6,7-chromone
4,9-dimethoxy-7-methylfuro[3,2-g]chromen-5-one
4,9-dimethoxy-7-methyl-furo[3,2-g]chromen-5-one
4,9-dimethoxy-7-methylfurano(3,2-g)chromen-5-one
5,8-dimethoxy-2-methyl-4’,5’-furano-6,7-chromone
4,9-dimethoxy-7-methyl-5H-furo[3,2-g]chromen-5-one
4,9-DIMETHOXY-7-METHYLFURO[3,2-G](1)BENZOPYRAN-5-ONE
4,9-dimethoxy-7-methyl-5-oxo-1,8-dioxabenz-(f)indene
4,9-dimethoxy-7-methyl-5-oxofuro(3,2-g)(1)benzopyran
4,9-dimethoxy-7-methyl-5-oxofuro(3,2-g)-1,2-chromene
2-g)(1)benzopyran-5-one,4,9-dimethoxy-7-methyl-5h-furo(
7-Methyl-4,9-dimethoxy-5H-furo[3,2-g][1]benzopyran-5-one
4,9-DIMETHOXY-7-METHYL-5H-FURO[3,2-G]-[1]BENZOPYRAN-5-ONE
4,9-Dimethoxy-7-methyl-5H-furo[3,2-g][1]benzopyran-5-one
Visammin | [EINECS(EC#)]
201-392-8 | [Molecular Formula]
C14H12O5 | [MDL Number]
MFCD00005007 | [MOL File]
82-02-0.mol | [Molecular Weight]
260.24 |
| Chemical Properties | Back Directory | [Melting point ]
150154°C
| [Boiling point ]
180200°C0.05mm Hg
| [density ]
1.1954 (rough estimate) | [refractive index ]
1.4560 (estimate) | [storage temp. ]
−20°C
| [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
crystalline
| [color ]
light yellow
| [Water Solubility ]
247.2g/L(25 ºC) | [Merck ]
14,5309 | [BRN ]
263185 | [Major Application]
food and beverages | [InChI]
1S/C14H12O5/c1-7-6-9(15)10-11(16-2)8-4-5-18-12(8)14(17-3)13(10)19-7/h4-6H,1-3H3 | [InChIKey]
HSMPDPBYAYSOBC-UHFFFAOYSA-N | [SMILES]
COc1c2OC(C)=CC(=O)c2c(OC)c3ccoc13 | [LogP]
1.770 (est) | [EPA Substance Registry System]
Khellin (82-02-0) |
| Hazard Information | Back Directory | [Uses]
vasodilator (coronary), photosensitizer | [Definition]
ChEBI: Khellin is a furanochrome in which the basic tricyclic skeleton is substituted at positions 4 and 9 with methoxy groups and at position 7 with a methyl group. A major constituent of the plant Ammi visnaga it is a herbal folk medicine used for various illnesses, its main effect being as a vasodilator. It has a role as a vasodilator agent, a bronchodilator agent, an anti-asthmatic agent and a cardiovascular drug. It is an organic heterotricyclic compound, an oxacycle and a furanochromone. It is functionally related to a 5H-furo[3,2-g]chromen-5-one. | [Brand name]
Ammivin (Marion Merrell Dow); Khelloyd
(Hoechst-Roussel). | [Synthesis Reference(s)]
Journal of Medicinal Chemistry, 26, p. 1672, 1983 DOI: 10.1021/jm00366a002 | [General Description]
Khellin, is reported to be an efficient drug for treating vitiligo when combined with ultraviolet A irradiation. | [Purification Methods]
Crystallise khellin from H2O, MeOH, pet ether or Et2O. The hydrochloride has m 98o(dec) (from EtOH/HCl). [Beilstein 19 II 236, 19 III/IV 2816, 19/6 V 320.] |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
25-38-36/37/38-23/24/25 | [Safety Statements ]
36/37/39-45-26 | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
LV1050000
| [HS Code ]
2932.99.7000 | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 | [Toxicity]
LD50 in mice, rats (mg/kg): 30.6, 34.4 i.v.; 50.8, 68.8 orally (Busch) |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
WG reagent
|
| Telephone: |
13391486464 |
| Website: |
www.wgchemical.com |
|