| Identification | Back Directory | [Name]
NSC 33994 | [CAS]
82058-16-0 | [Synonyms]
G6
NSC 33994
4,4′-(3E)-Hex-3-ene-3,4-diylbis{2-[(diethylamino)methyl]phenol}
(E)-4,4'-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylaMino)Methyl]phenol
4,4'-[(1E)-1,2-Diethyl-1,2-ethenediyl]bis[2-[(diethylaMino)Methyl]phenol
Phenol, 4,4'-[(1E)-1,2-diethyl-1,2-ethenediyl]bis[2-[(diethylamino)methyl]-
(E)-4,4′-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]-phenol (9CI) | [Molecular Formula]
C28H42N2O2 | [MDL Number]
MFCD20488055 | [MOL File]
82058-16-0.mol | [Molecular Weight]
438.65 |
| Chemical Properties | Back Directory | [Boiling point ]
524.7±45.0 °C(Predicted) | [density ]
1.040±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥25mg/mL | [form ]
powder | [pka]
9.20±0.50(Predicted) | [color ]
white to tan | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| Hazard Information | Back Directory | [Description]
NSC-33994 (82058-16-0) is a remarkably potent and selective JAK2 inhibitor (IC50 = 60 nM). Displays no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM.1?Suppresses JAK2-V617F-mediated human pathological cell growth?in vitro?and?in vivo2?and is concomitant with the disruption of intracellular vimentin filaments3. NSC-33994 reduces the tumorigenic potential of T98G glioblastoma cells?in vitro?and?in vivo.4 | [Uses]
NSC-33994 is novel inhibitor of JAK2 tyrosine kinase (Janus kinase 2 ). Janus kinase 2 (JAK2) plays a crucial role in the pathomechanism of myeloproliferative disorders and hematological malignancies. | [storage]
-20°C | [References]
1) Kiss?et al. (2009),?Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening; Bioorg. Med. Chem. Lett.,?19?3598
2) Kirabo?et al. (2011),?The stilbenoid tyrosine kinase inhibitor, G6, suppresses Jak2-V617F-mediated human pathological cell growth in vitro and in vivo; J. Biol. Chem.,?286?4280
3) Majumder?et al. (2011),?Cell death induced by the Jak2 inhibitor, G6, correlates with cleavage of vimentin filaments; Biochemistry,?50?7774
4) Baskin?et al. (2014),?The Jak2 small molecule inhibitor, G6, reduces the tumorigenic potential of T98G glioblastoma cells in vitro and in vivo; PLoS One,?9(8)?e105568 |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|