| Identification | Back Directory | [Name]
1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone | [CAS]
821794-92-7 | [Synonyms]
FMK
RSK2 kinase inhibitor
FMK - RSK inhibitor Fmk
1-(4-Amino-7-(3-hydroxypropyl)-5-(p-tolyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-fluoroethanone
1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone
Ethanone, 1-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoro-
1-[5-amino-9-(3-hydroxypropyl)-7-(4-methylphenyl)-2,4,9-triazabicyclo[4.3.0]nona-1,3,5,7-tetraen-8-yl]-2-fluoro-ethanone | [Molecular Formula]
C18H19FN4O2 | [MDL Number]
MFCD22417081 | [MOL File]
821794-92-7.mol | [Molecular Weight]
342.37 |
| Chemical Properties | Back Directory | [density ]
1.36 | [storage temp. ]
Store at -20°C | [solubility ]
insoluble in H2O; ≥17.1 mg/mL in DMSO; ≥28.7 mg/mL in EtOH | [form ]
solid | [color ]
White to light yellow | [InChI]
InChI=1S/C18H19FN4O2/c1-11-3-5-12(6-4-11)14-15-17(20)21-10-22-18(15)23(7-2-8-24)16(14)13(25)9-19/h3-6,10,24H,2,7-9H2,1H3,(H2,20,21,22) | [InChIKey]
IKLGYJACVCXYIL-UHFFFAOYSA-N | [SMILES]
C(=O)(C1N(CCCO)C2C(C=1C1=CC=C(C)C=C1)=C(N)N=CN=2)CF |
| Hazard Information | Back Directory | [Uses]
FMK is a potent irreversible RSK1/2 inhibitor (IC50 = 15 nM). Inactivates the C-terminal auto-kinase domain activity. Suppresses RSK2 kinase activity in RSK2-expressing HNSCC cell lines. Reduces HNSCC cell invasive ability. Displays no effect on EGF-stimulated phosphorylation of ERK1 or ERK2. | [target]
RSK1 | [IC 50]
RSK2 | [storage]
Store at -20°C |
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| Company Name: |
DKMbiochem.Co. Ltd Gold
|
| Telephone: |
15901859516 |
| Website: |
http://www.dkmbiochem.com/ |
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