| Identification | Back Directory | [Name]
L-Prolinamide, D-phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl]-, dihydrochloride (9CI) | [CAS]
82188-90-7 | [Synonyms]
Ppack HCl
PPACK (hydrochloride)
Fprmecl, dihydrochloride
L-Prolinamide, D-phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl]-, dihydrochloride (9CI) | [Molecular Formula]
C21H32Cl2N6O3 | [MOL File]
82188-90-7.mol | [Molecular Weight]
487.43 |
| Hazard Information | Back Directory | [Uses]
PPACK dihydrochloride is a plasminogen activator (rt-PA) inhibitor. PPACK dihydrochloride can inhibit changes in fibrin degradation products, plasminogen and alpha 2-antiplasmin. PPACK dihydrochloride also inhibits the binding of rt-PA to plasma protease inhibitors[1]. | [References]
[1] Mohler MA, et, al. D-Phe-Pro-Arg-chloromethylketone: its potential use in inhibiting the formation of in vitro artifacts in blood collected during tissue-type plasminogen activator thrombolytic therapy. Thromb Haemost. 1986 Oct 21;56(2):160-4. PMID:2433785 |
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