| Identification | Back Directory | [Name]
5(S), 15(S)-DIHETE | [CAS]
82200-87-1 | [Synonyms]
5,15-DiHETE
5(S), 15(S)-DIHETE
5(S),15(S)-DiHETE Lipid Maps MS Standard
5,15-dihydroxy-6,8,11,13-eicosatetraenoicacid
(5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-*eicosatetraen
(5S,15S)-DIHYDROXY-(6E,8Z,11Z,13E)-EICOS ATETRAENOI
5S,15S-DIHYDROXY-6E,8Z,11Z,13E-EICOSATETRAENOIC ACID
5(S),15(S)-DIHYDROXYEICOSA-6E,8Z,11Z,13E-TETRAENOIC ACID
5(S),15(S)-dihydroxy-6(E),8(Z),10(Z),13(E)-eicosatetraenoic aci
5(S),15(S)-Dihydroxy-6(E),8(Z),10(Z),13(E)-Eicosatetraenoic acid
6,8,11,13-Eicosatetraenoic acid, 5,15-dihydroxy-, (5S,6E,8Z,11Z,13E,15S)- | [Molecular Formula]
C20H32O4 | [MDL Number]
MFCD00063589 | [MOL File]
82200-87-1.mol | [Molecular Weight]
336.47 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 1 mg/ml | [form ]
Colorless liquid. | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
5(S),15(S)-DiHETE is synthesized by 15-LO from 5(S)-HETE. It potentiates the degranulation of human PMNL in response to PAF, but not fMLP, calcium ionophore A23187, or LTB4. 5(S),15(S)-DiHETE is chemotactic for eosinophils with an ED50 value of 0.3 μM. | [Uses]
5(S),15(S)-DiHETE is an enhancer of neutrophil degranulation and potent chemotaxin. | [Uses]
5(S),15(S)-DiHETE is synthesized by 15-LO from 5(S)-HETE. It potentiates the degranulation of human PMNL in response to PAF, but not fMLP, calcium ionophore A23187, or LTB4. 5(S),15(S)-DiHETE is chemotactic for eosinophils with an ED50 value of 0.3 μM. | [Definition]
ChEBI: 5(S),15(S)-DiHETE is a DiHETE that is (6E,8Z,11Z,13E)-icosatetraenoic acid in which the two hydroxy substituents are placed at the 5S- and 15S-positions. It has a role as a rat metabolite and a human xenobiotic metabolite. It is a conjugate acid of a 5(S),15(S)-DiHETE(1-). | [storage]
Store at -20°C, protect from light | [References]
[1] GREEN F A. Transformations of 5-HETE by activated keratinocyte 15-lipoxygenase and the activation mechanism[J]. Lipids, 1990, 25 10: 618-623. DOI: 10.1007/bf02536012
[2] JOSEPH T. O’FLAHERTY Michael J T. Effect of 15-lipoxygenase-derived arachidonate metabolites on human neutrophil degranulation[J]. Prostaglandins, leukotrienes, and medicine, 1985, 17 2: Pages 199-212. DOI: 10.1016/0262-1746(85)90107-6
[3] E. MORITA E C J Schr?der. Identification of a novel and highly potent eosinophil chemotactic lipid in human eosinophils treated with arachidonic acid.[J]. Journal of immunology, 1990, 144 5 1: 1893-1900. DOI: 10.4049/jimmunol.144.5.1893 |
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