| Identification | Back Directory | [Name]
3,6-dichloropyridazin-4-amine | [CAS]
823-58-5 | [Synonyms]
NSC 170664
4-Amino-3,6-dichL
3,6-dichloropyridazin-4-amine
4-Amino-3,6-dihydropyridazine
3,6-Dichloro-4-Pyridazinamine
3,6-Dichloro-4-aMinopyridazine
4-AMino-3,6-dichloropyridazine
4-AMino-3,6-dicholropyridazine
4-PyridazinaMine, 3,6-dichloro-
4-Amino-3,6-dichloropyridazine 98%
3,6-dichloropyridazin-4-amine ISO 9001：2015 REACH
3,6-Dichloropyridazin-4-amine, 4-Amino-3,6-dichloro-1,2-diazine | [Molecular Formula]
C4H3Cl2N3 | [MDL Number]
MFCD01647253 | [MOL File]
823-58-5.mol | [Molecular Weight]
163.99 |
| Chemical Properties | Back Directory | [Melting point ]
203 °C | [Boiling point ]
363.0±37.0 °C(Predicted) | [density ]
1.606±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [form ]
solid | [pka]
2.08±0.10(Predicted) | [color ]
Yellow-brown | [InChI]
InChI=1S/C4H3Cl2N3/c5-3-1-2(7)4(6)9-8-3/h1H,(H2,7,8) | [InChIKey]
HODYDVHWWMTUEL-UHFFFAOYSA-N | [SMILES]
C1(Cl)=NN=C(Cl)C=C1N |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 3,6-dichloropyridazin-4-amine from 3,4,6-trichloropyridazine:
Example 24A: 3,4,6-Trichloropyridazine (25 g, 136 mmol) was added to a 500 mL stainless steel pressure flask containing 14.8 N ammonium hydroxide solution (200 mL). The reaction mixture was stirred at 75°C for 16 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the solid product was collected by filtration to afford 17 g (76% yield) of the target compound 3,6-dichloropyridazin-4-amine. The product characterization data were as follows: 1H NMR (400 MHz, DMSO-d6) δ ppm 7.16 (s, 2H), 6.82 (s, 1H); MS (ESI+) m/z 164 (M+H)+. | [References]
[1] Journal of Organic Chemistry, 2014, vol. 79, # 21, p. 10311 - 10322
[2] Patent: US2017/15675, 2017, A1. Location in patent: Paragraph 1001
[3] Patent: US2009/163489, 2009, A1. Location in patent: Page/Page column 51
[4] Patent: US2014/349990, 2014, A1. Location in patent: Paragraph 1051; 1052
[5] Patent: WO2014/191896, 2014, A1. Location in patent: Page/Page column 217; 218 |
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