| Identification | Back Directory | [Name]
Deslorelin acetate | [CAS]
82318-06-7 | [Synonyms]
H 4065 Acetate
SoMagard Aceta
PTL 3001 Acetate
BacheM 9022 Acetate
D-Trp LHRH-PEA Acetate
Deslorelin Acetate(acetate)
D-Trp6-Pro9-N-ethylaMide-LH-RH Acetate
6-D-Tryptophan-9-(N-ethyl-L-prolinaMide)-1-9-luteinizing HorMone-releasing Factor (Swine) Monoacetate | [Molecular Formula]
C66H87N17O14 | [MDL Number]
MFCD09842868 | [MOL File]
82318-06-7.mol | [Molecular Weight]
1342.5 |
| Hazard Information | Back Directory | [Description]
Deslorelin Acetate is a synthetic nonapeptide analogue of the natural gonadotrophin releasing hormone (GnRH) with potential antineoplastic activity. Deslorelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Continuous, prolonged administration of goserelin in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. | [Uses]
Deslorelin acetate is an injectable gonadotropin-releasing hormone (GnRH) super-agonist (also known as an LHRH agonist), used in treatment of precocious puberty and commonly used in veterinary medicine to induce ovulation in mares.
| [Preparation]
Deslorelin acetate is synthesized from the corresponding protected amino acid monomers by solid or liquid phase synthesis. | [References]
[1] C L ACKERMANN. Ovarian activity reversibility after the use of deslorelin acetate as a short-term contraceptive in domestic queens.[J]. Theriogenology, 2012, 78 4: 817-822. DOI:10.1016/j.theriogenology.2012.03.030.
[2] R. NOVOTNY . Reversible suppression of sexual activity in tomcats with deslorelin implant[J]. Theriogenology, 2012, 78 4: Pages 848-857. DOI:10.1016/j.theriogenology.2012.03.035.
[3] Y CETIN. Long-term effect of deslorelin implant on ovarian pre-antral follicles and uterine histology in female rats.[J]. Reproduction in Domestic Animals, 2013, 48 2: 195-199. DOI:10.1111/j.1439-0531.2012.02128.x.
[4] BR?NDLI SP. Long-term effect of repeated deslorelin acetate treatment in bitches for reproduction control.[J]. Theriogenology, 2021: 73-82. DOI:10.1016/j.theriogenology.2021.07.015. |
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