| Identification | Back Directory | [Name]
[5-Methionine]Enkephalin, Enkephalin M | [CAS]
82362-17-2 | [Synonyms]
[5-Methionine]Enkephalin, Enkephalin M | [Molecular Formula]
C29H39N5O9S | [MDL Number]
MFCD00076415 | [MOL File]
82362-17-2.mol | [Molecular Weight]
633.72 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [form ]
powder | [color ]
white | [BRN ]
3042295 | [InChIKey]
NNACMJQGYXGHNE-DUQFDOSRSA-N | [SMILES]
O=C([C@H](CC1=CC=CC=C1)NC(CNC(CNC([C@@H](N)CC(C=C2)=CC=C2O)=O)=O)=O)N[C@@H](CCSC)C(O)=O.CC(O)=O.[H]O[H] |
| Hazard Information | Back Directory | [Uses]
[Met5] Enkephalin acetate salt hydrate has been used to study the effect of mutations in opioid growth factor receptor on growth of human cancer cell line. | [General Description]
[Met5] Enkephalin (ME) is an opioid pentapeptide, which acts as a neurotransmitter or neuromodulator in the central nervous system. [Met5] Enkephalin is activated on interaction with three main subtypes of receptors including μand δ opioid receptors mediating classic opioid effects of met-Enk and ζ -receptors mediating non-opioid actions of the peptide, i.e. retardation of cell growth. [Met5] Enkephalin is derived from precursor peptide pro-methionine-enkephalin in vitro consisting of H-Tyr-Gly-Gly-Phe-Met-Arg-OH amino acid sequence. The peptide activity is observed in the central nervous, neuroendocrine and immune systems. | [Biochem/physiol Actions]
Met-enkephalin is endogenous opioid neurotransmitter/neuromodulator with agonist activity at μ and δ opioid receptors. Enhancement of immune system function is mediated through met-enkephalin receptors on leukocytes. Met-enkephalin also functions as a growth factor on many cell types at a receptor that is distinct from the neuronal opioid receptors. |
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