| Identification | Back Directory | [Name]
3,11a-Epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione, 2,3,5a,6,10b,11-hexahydro-11-hydroxy-3-(hydroxymethyl)-10b-(1H-indol-3-yl)-2-methyl-, (3S,5aR,10bR,11S,11aS)- | [CAS]
823802-57-9 | [Synonyms]
T988C
3,11a-Epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione, 2,3,5a,6,10b,11-hexahydro-11-hydroxy-3-(hydroxymethyl)-10b-(1H-indol-3-yl)-2-methyl-, (3S,5aR,10bR,11S,11aS)- | [Molecular Formula]
C23H20N4O4S2 | [MOL File]
823802-57-9.mol | [Molecular Weight]
480.56 |
| Hazard Information | Back Directory | [Uses]
T988C is a heptacyclic epidithiodioxopiperazine (ETP) natural product. T988C shows strong cytotoxicity to cultured P388 leukemia cells[1]. | [References]
[1] DeLorbe JE, et al. General approach for preparing epidithiodioxopiperazines from trioxopiperazine precursors: enantioselective total syntheses of (+)- and (-)-gliocladine C, (+)-leptosin D, (+)-T988C, (+)-bionectin A, and (+)-gliocladin A. J Am Chem Soc. 2013 Mar 13;135(10):4117-28. DOI:10.1021/ja400315y
[2] Feng Y, et al. Novel cytotoxic thiodiketopiperazine derivatives from a Tilachlidium sp. J Nat Prod. 2004 Dec;67(12):2090-2. DOI:10.1021/np030326w |
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