| Identification | Back Directory | [Name]
Myristic Acid Alkyne | [CAS]
82909-47-5 | [Synonyms]
Myristic Acid Alkyne
13-Tetradecynoic Acid
Alkynyl Myristic Acid
tetradec-13-ynoic acid | [Molecular Formula]
C14H24O2 | [MDL Number]
MFCD18382104 | [MOL File]
82909-47-5.mol | [Molecular Weight]
224.34 |
| Chemical Properties | Back Directory | [Melting point ]
59.1°C (estimate) | [Boiling point ]
384.08°C (rough estimate) | [density ]
0.9192 (rough estimate) | [refractive index ]
1.4154 (estimate) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 12.5 mg/ml; Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml | [form ]
Solid | [pka]
4.78±0.10(Predicted) | [color ]
Light yellow to brown | [InChI]
InChI=1S/C14H24O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h1H,3-13H2,(H,15,16) | [InChIKey]
JNXXRQLAAJXERE-UHFFFAOYSA-N | [SMILES]
C(O)(=O)CCCCCCCCCCCC#C |
| Hazard Information | Back Directory | [Description]
Alkynyl myristic acid can be used to identify and characterize the post-translational myristylated proteins with Click Chemistry. | [Uses]
Alkynyl myristic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Alkynyl myristic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
Alkyl-Chain | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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