| Identification | Back Directory | [Name]
(3beta,24S)-stigmast-5-en-3-ol | [CAS]
83-47-6 | [Synonyms]
Clionasterol
g-Sitosterol
gamma-sitosterol
Einecs 201-481-1
beta-Dihydrofucosterol
(24S)-Stigmast-5-en-3β-ol
22,23-Dihydroporiferasterol
(3b,24S)-stigmast-5-en-3-ol
Stigmast-5-en-3-ol, (3β,24S)-
Stigmast-5-en-3-ol, (3b,24S)-
(3beta,24S)-stigmast-5-en-3-ol | [EINECS(EC#)]
201-481-1 | [Molecular Formula]
C29H50O | [MOL File]
83-47-6.mol | [Molecular Weight]
414.71 |
| Chemical Properties | Back Directory | [Boiling point ]
473.52°C (rough estimate) | [density ]
0.9540 (rough estimate) | [refractive index ]
1.5000 (estimate) | [Melting point ]
147 °C | [pka]
15.03±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
γ-Sitosterol is an inhibitor for c-Myc. γ-Sitosterol inhibits the proliferation of cancer cell MCF-7 and A549 with IC50 of 240.73 μg/mL and 696.6 μg/mL, arrests the cell cycle at G2/M phase, and induces apoptosis. γ-Sitosterol upregulates the expression of cell cycle regulators cyclin B/E[1]. | [Definition]
ChEBI: Clionasterol is a member of the class of phytosterols that is poriferast-5-ene carrying a beta-hydroxy substituent at position 3. It has a role as a plant metabolite and a marine metabolite. It is a 3beta-sterol, a member of phytosterols and a 3beta-hydroxy-Delta(5)-steroid. It derives from a hydride of a poriferastane. | [References]
[1] Sundarraj S, et al., γ-Sitosterol from Acacia nilotica L. induces G2/M cell cycle arrest and apoptosis through c-Myc suppression in MCF-7 and A549 cells. J Ethnopharmacol. 2012 Jun 14;141(3):803-9. DOI:10.1016/j.jep.2012.03.014 |
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