| Identification | Back Directory | [Name]
5-PyriMidinecarboxylic acid, 4-[1,1'-biphenyl]-4-yl-1-[6-[[2-(butylaMino)-1-[3-(Methoxycarbonyl)-4-(2-Methoxy-2-oxoethoxy)phenyl]-2-oxoethyl]hexylaMino]-6-oxohexyl]-1,2,3,4-tetrahydro-6-Methyl-2-oxo-, phenylMethyl ester | [CAS]
831217-40-4 | [Synonyms]
MAL3-101
benzyl 4-([1,1'-biphenyl]-4-yl)-1-(6-((2-(butylamino)
-1-(4-(2-methoxy-2-oxoethoxy)-3-(methoxycarbonyl)phenyl)-2-oxoethyl)(hexyl)amino)-6-oxohexyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
5-PyriMidinecarboxylic acid, 4-[1,1'-biphenyl]-4-yl-1-[6-[[2-(butylaMino)-1-[3-(Methoxycarbonyl)-4-(2-Methoxy-2-oxoethoxy)phenyl]-2-oxoethyl]hexylaMino]-6-oxohexyl]-1,2,3,4-tetrahydro-6-Methyl-2-oxo-, phenylMethyl ester | [Molecular Formula]
C54H66N4O10 | [MDL Number]
MFCD20257231 | [MOL File]
831217-40-4.mol | [Molecular Weight]
931.123 |
| Chemical Properties | Back Directory | [Boiling point ]
1037.1±65.0 °C(Predicted) | [density ]
1.165±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
11.16±0.70(Predicted) | [color ]
Off-white to light brown |
| Hazard Information | Back Directory | [Description]
MAL3-101 is a heat shock protein 70 molecular chaperone inhibitor. | [Uses]
MAL3-101 is a potent HSP70 allosteric inhibitor. MAL3-101 inhibits HSP70 ATPase activity by blocking Hsp40 co-chaperone interaction. MAL3-101 can be used for researching muscle invasive bladder cancer (MIBC)[1]. | [IC 50]
HSP70 | [References]
[1] Prince T, et al. Dual targeting of HSP70 does not induce the heat shock response and synergistically reduces cell viability in muscle invasive bladder cancer. Oncotarget. 2018 Aug 24;9(66):32702-32717. DOI:10.18632/oncotarget.26021 |
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| Company Name: |
AstaTech, Inc
|
| Tel: |
(215) 785 3197 |
| Website: |
www.astatechinc.com |
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