| Identification | Back Directory | [Name]
GLX351322 | [CAS]
835598-94-2 | [Synonyms]
CS-2871
GLX 351322;GLX-351322
4H-Cyclopenta[b]thiophene-3-carboxylic acid, 2-[[2-[4-(2-furanylcarbonyl)-1-piperazinyl]acetyl]amino]-5,6-dihydro-, ethyl ester | [Molecular Formula]
C21H25N3O5S | [MDL Number]
MFCD05123600 | [MOL File]
835598-94-2.mol | [Molecular Weight]
431.51 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO:20.0(Max Conc. mg/mL);46.35(Max Conc. mM)
DMF:1.0(Max Conc. mg/mL);2.32(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.76(Max Conc. mM)
Ethanol:4.0(Max Conc. mg/mL);9.27(Max Conc. mM) | [form ]
A crystalline solid | [color ]
White to off-white | [InChIKey]
KEVHLTCEMHIJTQ-UHFFFAOYSA-N | [SMILES]
O=C(C1=C(NC(CN2CCN(C(C3=CC=CO3)=O)CC2)=O)SC4=C1CCC4)OCC |
| Hazard Information | Back Directory | [Uses]
GLX351322 is an inhibitor of NADPH oxidase 4 (Nox4), and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μM. | [Biological Activity]
GLX351322 is an inhibitor of NADPH oxidase 4 (NOX4). It can inhibits tetracycline-induced hydrogen peroxide production in NOX4-overexpressing cells with IC50 of 5 μM. | [in vitro]
GLX351322 is an inhibitor of NADPH oxidase 4, and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC 50 of 5 μM. GLX351322 shows weak activity against NOX2 in hPBMC cells ( IC 50 , 40 μM). | [in vivo]
GLX351322 (3.8 mg/kg/day, po) ameliorates HFD-induced hyperglycemia in mice. | [target]
| Target | Value | NOX4
(Cell-free assay) | 5 μM |
| [IC 50]
NOX4 | [References]
[1] Anvari E, et al. The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice. Free Radic Res. 2015;49(11):1308-18. DOI:10.3109/10715762.2015.1067697 |
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| Company Name: |
Cckinase, Inc.
|
| Tel: |
+1 (732)236-3202 |
| Website: |
www.cckinase.com |
|