| Identification | Back Directory | [Name]
Piperaquine | [CAS]
83764-65-2 | [Synonyms]
Piperaquine
Brn 0905079
Piperaquine USP/EP/BP
Quinoline, 4,4'-(trimethylenedi-4,1-piperazinediyl)bis(7-chloro-
Quinoline, 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis(7-chloro- (9ci) | [Molecular Formula]
C29H32Cl2N6 | [MOL File]
83764-65-2.mol | [Molecular Weight]
535.511 |
| Hazard Information | Back Directory | [Pharmaceutical Applications]
A bisquinoline used to treat malaria in China since 1978. It
is structurally related to chloroquine, but active against chloroquine-
resistant P. falciparum. A combination with dihdyroartemisinin
has shown excellent tolerability and high cure
rates for multidrug-resistant falciparum malaria.
It is highly lipid-soluble and orally well absorbed. The elimination
half-life is 20–30 days and there is extensive metabolism.
Adverse effects are similar to chloroquine, but pruritus
is uncommon. |
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