| Identification | Back Directory | [Name]
4-[4,4-bis(4-fluorophenyl)butyl]-3-carbamoyl-N-(2,6-dichlorophenyl)piperazine-1-acetamide dihydrochloride | [CAS]
83898-67-3 | [Synonyms]
R-51469
Mioflazine hydrochloride anhydrous
4-[4,4-bis(4-fluorophenyl)butyl]-3-carbamoyl-N-(2,6-dichlorophenyl)piperazine-1-acetamide dihydrochloride | [EINECS(EC#)]
281-279-8 | [Molecular Formula]
C29H33Cl4F2N4O2 | [MOL File]
83898-67-3.mol | [Molecular Weight]
649.407 |
| Hazard Information | Back Directory | [Uses]
Mioflazine dihydrochloride is a nucleoside transport inhibitor with sleep-improving activity. Mioflazine dihydrochloride significantly improves cardiac survival after global cardiac ischemia. Mioflazine dihydrochloride reduces the mitochondrial calcium content in guinea-pig. Mioflazine dihydrochloride does not exhibit inotropic effects during induction and nursing[1][2][3][4]. | [References]
[1] Wauquier A, et al. Sleep improvement in dogs after oral administration of mioflazine, a nucleoside transport inhibitor. Psychopharmacology (Berl). 1987;91(4):434-9. DOI:10.1007/BF00216007
[2] Mioflazine, a potentially protective drug against ischaemic damage: a study in dogs DOI:10.1093/oxfordjournals.eurheartj.a061922
[3] Pirovano IM, et al. Inhibition of nucleoside uptake in human erythrocytes by a new series of compounds related to lidoflazine and mioflazine. Eur J Pharmacol. 1990 Dec 15;189(6):419-22. DOI:10.1016/0922-4106(90)90040-5
[4] J G Hugtenburg, et al. The influence of nifedipine and mioflazine on mitochondrial calcium overload in normoxic and ischaemic guinea-pig hearts. Eur J Pharmacol. 1990 Mar 13;178(1):71-8. DOI:10.1016/0014-2999(90)94794-x |
|
|