| Identification | Back Directory | [Name]
3-amino-N-(2,4-dibromophenyl)-6-(pyridin-3-yl)thieno[2,3-b]pyridine-2-carboxamide | [CAS]
840461-03-2 | [Synonyms]
SOD1-Derlin-1 Inhibitor 56-20
3-amino-N-(2,4-dibromophenyl)-6-(pyridin-3-yl)thieno[2,3-b]pyridine-2-carboxamide | [Molecular Formula]
C19H12Br2N4OS | [MOL File]
840461-03-2.mol | [Molecular Weight]
504.2 |
| Chemical Properties | Back Directory | [Boiling point ]
605.4±55.0 °C(Predicted) | [density ]
1.811±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
9.81±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
SOD1-Derlin-1 Inhibitor 56-20 is a potent inhibitor of SOD1-Derlin-1 interaction. | [Uses]
SOD1-Derlin-1 inhibitor-1 (compound 56-20) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-1 inhibits SOD1G93A-Derlin-1 complex with an IC50 value of 7.11 μM. SOD1-Derlin-1 inhibitor-1 can be used for the research of amyotrophic lateral sclerosis[1]. | [References]
[1] Tsuburaya N, et al. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model. Nat Commun. 2018 Jul 10;9(1):2668. DOI:10.1038/s41467-018-05127-2 |
|
|