| Identification | Back Directory | [Name]
Quinol 1h | [CAS]
840474-95-5 | [Synonyms]
Quinol 1h
4-[1-(benzenesulfonyl)-6-fluoro-1H-indol-2-yl]-4-hydroxycyclohexa-2,5-dien-1-one | [Molecular Formula]
C20H14FNO4S | [MOL File]
840474-95-5.mol | [Molecular Weight]
383.39 |
| Chemical Properties | Back Directory | [Melting point ]
185-187 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
653.3±65.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [pka]
10.80±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
AJM 290 is a Trx-1 inhibitor. AJM 290 is an inhibitor of the HIF-1α COOH-terminal transactivation domain, and blocks HIF-1 binding to DNA[1]. | [References]
[1] Martin AR,et al. Hypoxia inducible factor down-regulation, cancer and cancer stem cells (CSCs): ongoing success stories. Medchemcomm. 2016 Oct 19;8(1):21-52. DOI:10.1039/c6md00432f |
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