| Identification | Back Directory | [Name]
XEN 103 | [CAS]
840489-44-3 | [Synonyms]
XEN 103
3-Pyridazinecarboxamide, N-(2-cyclopropylethyl)-6-[4-[5-fluoro-2-(trifluoromethyl)benzoyl]-1-piperazinyl]- | [Molecular Formula]
C22H23F4N5O2 | [MDL Number]
MFCD24539452 | [MOL File]
840489-44-3.mol | [Molecular Weight]
465.44 |
| Hazard Information | Back Directory | [Uses]
XEN103 is a SCD1 inhibitor, with IC50s of 14 nM and 12 nM for mSCD1 and SCD1 in HepG2 cell. XEN103 can be used for research of obesity and type 2 diabetes. XEN103 also induces sebaceous gland atrophy in mice[1][2]. | [References]
[1] Zhang Z, et al. Discovery of piperazin-1-ylpyridazine-based potent and selective stearoyl-CoA desaturase-1 inhibitors for the treatment of obesity and metabolic syndrome. J Med Chem. 2013 Jan 24;56(2):568-83. DOI:10.1021/jm301661h
[2] Meingassner JG, et al. Pharmacological inhibition of stearoyl CoA desaturase in the skin induces atrophy of the sebaceous glands. DOI:10.1038/jid.2013.89 |
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| Company Name: |
Key Organics Ltd.
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| Tel: |
+44 (0) 1840-212137 |
| Website: |
www.keyorganics.net |
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