| Identification | Back Directory | [Name]
BMS-538305 HCl | [CAS]
841302-51-0 | [Synonyms]
BMS538305
BMS-538305
BMS 538305
BMS-538305 HCl
BMS-538305 hydrochloride | [Molecular Formula]
C17H27ClN2O2 | [MOL File]
841302-51-0.mol | [Molecular Weight]
326.87 |
| Hazard Information | Back Directory | [Description]
BMS-538305 is a potent and selective dipeptidyl peptidase IV (DPP-IV) inhibitor. | [Uses]
BMS-538305 hydrochloride is a potent and selective inhibitor of dipeptidyl peptidase IV (DPP-IV), exhibiting strong biological activity by forming a reversible covalent complex with the enzyme. BMS-538305 hydrochloride demonstrates its mechanism of action through the covalent attachment between the nitrile carbon of the inhibitor and the enzyme residue S630, as unveiled by the X-ray crystal structure analysis. | [References]
[1] Involvement of DPP-IV catalytic residues in enzyme-saxagliptin complex formation |
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