| Identification | Back Directory | [Name]
Ethanone, 1-(6-fluoro-3-pyridinyl)- (9CI) | [CAS]
84331-14-6 | [Synonyms]
5-Acetyl-2-fluoropyridine
5-Acethyl-2-fluoropyridine
1-(6-Fluoro-3-pyridyl)ethanone
1-(6-Fluoro-3-pyridinyl)-ethanone
Ethanone, 1-(6-fluoro-3-pyridinyl)-
1-(6-Fluoropyridin-3-yl)ethanone 95+%
Ethanone, 1-(6-fluoro-3-pyridinyl)- (9CI)
Ethanone, 1-(6-fluoro-3-pyridinyl)- (9CI) ISO 9001：2015 REACH | [Molecular Formula]
C7H6FNO | [MDL Number]
MFCD07375076 | [MOL File]
84331-14-6.mol | [Molecular Weight]
139.13 |
| Chemical Properties | Back Directory | [Boiling point ]
246.7±20.0℃ (760 Torr) | [density ]
1.175±0.06 g/cm3 (20 ºC 760 Torr) | [Fp ]
103.0±21.8℃ | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
-2.23±0.10(Predicted) | [Appearance]
White to light yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
To a cold solution (-78°C) of 6-fluoro-N-methoxy-N-methylnicotinamide (Method 38, 7.2 g, 39 mmol) in tetrahydrofuran (130 mL) was added slowly and dropwise methylmagnesium bromide (20 mL, 59 mmol, 3 M ether solution). The cooling bath was removed and the reaction mixture was allowed to gradually warm to room temperature with continuous stirring for 2 hours. Upon completion of the reaction, the reaction was quenched with 3 N hydrochloric acid solution and the layers were separated. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 3.8 g of 2-fluoro-5-acetylpyridine in 70% yield. The product was characterized by 1H NMR (CDCl3): δ 8.80 (s, 1H), 8.29-8.43 (m, 1H), 6.98-7.06 (m, 1H), 2.62 (s, 3H). | [References]
[1] Patent: WO2006/82392, 2006, A1. Location in patent: Page/Page column 116
[2] Patent: US2017/313683, 2017, A1. Location in patent: Paragraph 1251-1252 |
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