| Identification | Back Directory | [Name]
Octadecanedioic acid, 1-(1,1-dimethylethyl) 18-(2,5-dioxo-1-pyrrolidinyl) ester | [CAS]
843666-34-2 | [Synonyms]
Boc-C16-NHS ester
SemaglutideImpurity7
t-butyl-octadecanedioate-NHS ester
1-tert-Butyl 18-(2,5-dioxopyrrolidin-1-yl) octadecanedioate
Octadecanedioic acid, 1-(1,1-dimethylethyl) 18-(2,5-dioxo-1-pyrrolidinyl) ester | [Molecular Formula]
C26H45NO6 | [MDL Number]
MFCD29923003 | [MOL File]
843666-34-2.mol | [Molecular Weight]
467.64 |
| Chemical Properties | Back Directory | [Boiling point ]
537.7±42.0 °C(Predicted) | [density ]
1.05±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [form ]
Solid | [color ]
White to off-white | [InChI]
InChI=1S/C26H45NO6/c1-26(2,3)32-24(30)18-16-14-12-10-8-6-4-5-7-9-11-13-15-17-19-25(31)33-27-22(28)20-21-23(27)29/h4-21H2,1-3H3 | [InChIKey]
JTOVMMPSILRQQJ-UHFFFAOYSA-N | [SMILES]
C(OC(C)(C)C)(=O)CCCCCCCCCCCCCCCCC(ON1C(=O)CCC1=O)=O |
| Hazard Information | Back Directory | [Description]
t-butyl-octadecanedioate-NHS ester has a t-butyl ester group and an NHS ester moiety. The t-butyl group can be deprotected under acidic conditions. NHS ester can react specifically and efficiently with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic condition to form a covalent bond. | [Uses]
Boc-C16-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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