| Identification | Back Directory | [Name]
3'-amino-2',3'-dideoxyuridine | [CAS]
84472-86-6 | [Synonyms]
AMDU
3'-NH2-ddU
3'-amino-2',3'-dideoxyuridine
Uridine, 3'-amino-2',3'-dideoxy-
5-(azidomethyl)-2′-deoxyuridine (AmdU)
5-(azidomethyl)-1-((2R,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione | [Molecular Formula]
C9H13N3O4 | [MDL Number]
MFCD00872044 | [MOL File]
84472-86-6.mol | [Molecular Weight]
227.22 |
| Chemical Properties | Back Directory | [Melting point ]
174-176℃ | [density ]
1.425 | [form ]
solid | [pka]
9.39±0.10(Predicted) | [InChI]
1S/C10H13N5O5/c11-14-12-2-5-3-15(10(19)13-9(5)18)8-1-6(17)7(4-16)20-8/h3,6-8,16-17H,1-2,4H2,(H,13,18,19)/t6-,7+,8+/m0/s1 | [InChIKey]
JKSAKMHLWMCADM-XLPZGREQSA-N | [SMILES]
O[C@@H]1[C@@H](CO)O[C@@H](N2C(NC(C(CN=[N+]=[N-])=C2)=O)=O)C1 |
| Hazard Information | Back Directory | [Uses]
5-(Azidomethyl)-2′-deoxyuridine (AmdU) exhibits good chemical stability and the ability to metabolically label cellular DNA. Following its incorporation into cellular DNA by endogenous enzymes, AmdU can be detected using both copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC) reactions.
An Azide-Modified Nucleoside for Metabolic Labeling of DNA |
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