| Identification | Back Directory | [Name]
2-Chloro-3-nitropyridine-6-amine | [CAS]
84487-03-6 | [Synonyms]
6-Chloro-5-nitropyridin-2-aMine
2-Chloro-3-nitropyridine-6-amine
6-Amino-2-chloro-3-nitropyridine
2-Amino-6-chloro-5-nitropyridine
2-Pyridinamine, 6-chloro-5-nitro-
6-Chloro-5-nitro-pyridin-2-ylaMine
2-Chloro-3-nitropyridine-6-amine ISO 9001：2015 REACH | [Molecular Formula]
C5H4ClN3O2 | [MDL Number]
MFCD01692500 | [MOL File]
84487-03-6.mol | [Molecular Weight]
173.56 |
| Chemical Properties | Back Directory | [Melting point ]
188 °C | [Boiling point ]
393.6±37.0 °C(Predicted) | [density ]
1.596±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [pka]
-1.22±0.37(Predicted) | [Appearance]
Yellow to green Solid |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of 2-amino-5-nitro-6-chloropyridine from 2-amino-6-chloropyridine was as follows: concentrated nitric acid (2.39 mL, 35.00 mmol) was slowly added dropwise at 0 °C to a mixture containing concentrated sulfuric acid (56 mL, 1050 mmol) and 6-chloropyridin-2-amine (3.00 g, 23.34 mmol). The reaction mixture was kept stirred at 0 °C for 4 hours. After completion of the reaction, the mixture was carefully poured into ice water. The mixture was extracted with ethyl acetate (3 x 100 mL). The organic layers were combined, dried with anhydrous sodium sulfate and subsequently concentrated. The residue was purified by column chromatography to afford the target product 2-amino-5-nitro-6-chloropyridine (1.38 g, 34% yield). | [References]
[1] Patent: WO2018/146472, 2018, A1. Location in patent: Page/Page column 54; 55
[2] Patent: WO2018/146469, 2018, A1. Location in patent: Page/Page column 44-45 |
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