| Identification | Back Directory | [Name]
Evodenoson | [CAS]
844873-47-8 | [Synonyms]
DE112
DE-112
ATL313
DE 112
Evodenoson
1-Piperidinecarboxylic acid, 4-[3-[6-amino-9-(N-cyclopropyl-β-D-ribofuranuronamidosyl)-9H-purin-2-yl]-2-propyn-1-yl]-, methyl ester | [Molecular Formula]
C23H29N7O6 | [MOL File]
844873-47-8.mol | [Molecular Weight]
499.53 |
| Hazard Information | Back Directory | [Uses]
Evodenoson is a selective agonist of the A2A adenosine receptor. Evodenoson’s primary actions include reducing inflammatory responses, decreasing intestinal fluid secretion, edema, tissue damage, and neutrophil infiltration induced by Clostridium difficile toxin A. Evodenoson’s protective effect is achieved by reducing myeloperoxidase (MPO) and adenosine deaminase (ADA) activities, and by lowering the production of tumor necrosis factor-alpha (TNF-α)[1]. | [IC 50]
A2AR | [References]
[1] Cavalcante IC, et al. Effect of novel A2A adenosine receptor agonist ATL 313 on Clostridium difficile toxin A-induced murine ileal enteritis. Infect Immun. 2006 May;74(5):2606-12. |
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