| Identification | Back Directory | [Name]
3-[2-[2-cyclopentyl-6-(4-diMethylphosphorylanilino)purin-9-yl]ethyl]phenol | [CAS]
845895-51-4 | [Synonyms]
AP23464
3-[2-[2-cyclopentyl-6-(4-diMethylphosphorylanilino)purin-9-yl]ethyl]phenol
3-[2-[2-Cyclopentyl-6-[[4-(dimethylphosphinyl)phenyl]amino]-9H-purin-9-yl]ethyl]-phenol
Phenol, 3-[2-[2-cyclopentyl-6-[[4-(dimethylphosphinyl)phenyl]amino]-9H-purin-9-yl]ethyl]- | [Molecular Formula]
C26H30N5O2P | [MOL File]
845895-51-4.mol | [Molecular Weight]
475.52 |
| Hazard Information | Back Directory | [Uses]
AP23464 is an ATP-based inhibitor for Kit, that inhibits the phosphorylation of Kit wildtype and mutants, with IC50 of 5-85 nM. AP23464 inhibits the proliferation of Kit mutated cells (IC50 is 3-20 nM), arrests the cell cycle at G0/G1 phase, and induces apoptosis in Kit mutated cells[1]. | [References]
[1] Corbin AS, et al., In vitro and in vivo activity of ATP-based kinase inhibitors AP23464 and AP23848 against activation-loop mutants of Kit. Blood. 2005 Jul 1;106(1):227-34. DOI:10.1182/blood-2004-12-4771 |
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| Company Name: |
BOC Sciences
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1-631-485-4226; 16314854226 |
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https://www.bocsci.com |
| Company Name: |
Tcichem, Inc.
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13918644899 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList19113/0.htm |
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