| Identification | Back Directory | [Name]
4-FLUORO-4-PIPERIDINE ETHYLCARBOXYLATE HYDROCHLORIDE | [CAS]
845909-49-1 | [Synonyms]
Ethyl 4-fluoropiperidine-4-carboxylate, HCl
ethyl 4-fluoropiperidin-1-ium-4-carboxylate
Ethyl 4-fluoro-4-piperidinecarboxylate hydrochloride
4-FLUORO-4-PIPERIDINE ETHYLCARBOXYLATE HYDROCHLORIDE
Ethyl 4-Fluoropiperidine-4-carboxylate Hydrochloride | [Molecular Formula]
C8H15ClFNO2 | [MDL Number]
MFCD09880187 | [MOL File]
845909-49-1.mol | [Molecular Weight]
211.67 |
| Hazard Information | Back Directory | [Uses]
Ethyl 4-fluoropiperidine-4-carboxylate, HCl | [Synthesis]
General procedure for the synthesis of ethyl 4-fluoro-4-piperidinecarboxylate hydrochloride from ethyl N-Boc-4-fluoro-4-piperidinecarboxylate: To a solution of tert-butyl 4-chloro-4-tert-butyl-4-fluoro-piperidine-1,4-dicarboxylate (15 g, 54.48 mmol, 1.00 eq.) in methylene chloride (150 mL), a solution of 4 M hydrogen chloride in dioxane (100 mL) was added. The reaction mixture was stirred at 25 °C overnight. Upon completion of the reaction, the mixture was concentrated under reduced pressure to afford 11 g (95% yield) of ethyl 4-fluoropiperidine-4-carboxylate hydrochloride as a white solid. | [References]
[1] Patent: US2018/79742, 2018, A1. Location in patent: Paragraph 0328; 0329
[2] Patent: US2012/88750, 2012, A1. Location in patent: Page/Page column 34; 35
[3] Patent: US2018/258076, 2018, A1. Location in patent: Paragraph 0506 |
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