| Identification | Back Directory | [Name]
OLEYLOXYETHYL PHOSPHORYLCHOLINE | [CAS]
84601-19-4 | [Synonyms]
OLEYLOXYETHYLPHOSPHOCHOLINE
NPLMVGGTFDUQHL-SEYXRHQNSA-N
OLEYOXYETHYL PHOSPHORYLCHOLINE
OLEYLOXYETHYL PHOSPHORYLCHOLINE
PHOSPHORYLCHOLINE, OLEOYLOXYETHYL ESTER
OLEYLOXYETHYL PHOSPHORYLCHOLINE USP/EP/BP
1-O-9Z-OCTADECENYLETHYLENEGLYCOL-2-O-PHOSPHORYLCHOLINE
(17Z)-4-Hydroxy-N,N,N-trimethyl-3,5,8-trioxa-4-phosphahexacos-17-en-1-aminium inner salt 4-oxide | [Molecular Formula]
C25H52NO5P | [MDL Number]
MFCD00077383 | [MOL File]
84601-19-4.mol | [Molecular Weight]
477.67 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
≤16mg/ml in DMSO;16mg/ml in dimethyl formamide | [form ]
solution in ethanol. | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Oleyloxyethyl phosphorylcholine is an inhibitor of PLA2 with an IC50 value of 6.2 μM for porcine pancreatic PLA2. | [in vitro]
to examine the phospholipids including oleyloxyethyl phosphorylcholine as pla2 inhibitors, the enzyme assay was employed. determinations were performed below critical micelle concentration. porcine pancreatic pla2 and phospholipid inhibitor were preincubated for 2 min at 37°c in buffer at ph 8.5. introduction of [l4c]arachidonate phosphatidylcholine initiated the enzymatic reaction, which is quenched after 5 min at 37°c. in this manner 50% inhibitor concentrations were determined for mepacrine and alkylphosphorylcholines, indicating oleyloxyethyl phosphorylcholine was an inhibitor of pla2 with an ic50 of 6.2 μm for porcine pancreatic pla2 [1]. | [IC 50]
6.2 μm for porcine pancreatic pla2 | [References]
[1] magolda, r. l.,ripka, w.c.,galbraith, w., et al. novel synthesis of potent site-specific phospholipase a2 inhibitors. book: prostaglandins, leukotrienes and lipoxins 669-676 (1985). |
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| Company Name: |
Enzo Biochem Inc
|
| Tel: |
Enzo Biochem Inc. 13797054060 |
| Website: |
www.enzo.com |
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