| Identification | Back Directory | [Name]
Compound 48/80 (hydrochloride) | [CAS]
848035-21-2 | [Synonyms]
C48/80 trihydrochloride
Compound 48/80 (hydrochloride) | [Molecular Formula]
C32H48Cl3N3O3 | [MDL Number]
MFCD04108752 | [MOL File]
848035-21-2.mol | [Molecular Weight]
629.101 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C, sealed storage, away from moisture ,protect from light | [solubility ]
Water: 100 mM | [form ]
A solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C activity from human platelets [1][2][3]. | [Biological Activity]
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of N-methyl-p-methoxyphenethylamine and formaldehyde condensation products. It is also a histamine releaser and mast cell degranulator. It inhibits the activity of phosphatidylinositol-specific phospholipase C in human platelets. | [in vitro]
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) inhibits both cytosolic and particulate phosphatidylinositol-specific phospholipase C activities with a similar efficiency; IC 50 values are 2.1 μg/ml (supernatant ) and 5.0 μg /ml (particulate fraction). The aggregation of human platelets induced by ADP and PAF-acether is inhibited by Compound 48/80. < /div> | [in vivo]
Compound 48/80 trihydrochloride (0.75 mg/kg; ip; Killed after 0.5, 3 or 6 h) increases serum serotonin, histamine and corticosterone levels at 0.5 h, but their increases were reduced thereafter.
Compound 48/80 trihydrochloride causes oxidative stress in rat adrenal gland through mast cell degranulation. | Animal Model: | 7-week-old Wistar male rats (fasted for 24 hours) | | Dosage: | 0.75 mg/kg | | Administration: | Intraperitoneal injection; Killed after 0.5, 3 or 6 h | | Result: | Serum histamine and serotonin concentrations significantly higher than those in untreated control rats at 0.5 h after treatment. The increased serum histamine and serotonin conc entrations in rats decreased time-dependently thereafter. | | [storage]
Store at -20°C, sealed storage, away from moisture ,protect from light | [References]
[1] Bronner C, et al. Compound 48/80 is a potent inhibitor of phospholipase C and a dual modulator of phospholipase A2 from human platelet. Biochim Biophys Acta. 1987 Aug 15;920(3):301-5. DOI:10.1016/0005-2760(87)90108-1
[2] Schemann M, et al. The mast cell degranulator compound 48/80 directly activates neurons. PLoS One. 2012;7(12):e52104. DOI:10.1371/journal.pone.0052104
[3] Kaida S, et al. Compound 48/80 causes oxidative stress in the adrenal gland of rats through mast cell degranulation. Free Radic Res. 2010 Feb;44(2):171-80. DOI:10.3109/10715760903380466 |
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