| Identification | Back Directory | [Name]
3-Chloro-2-(4-hydroxyphenyl)-2H-indazol-5-ol | [CAS]
848142-62-1 | [Synonyms]
Indazole-Cl
3-chloro-2-(4-hydroxyphenyl)indazol-5-ol
3-Chloro-2-(4-hydroxyphenyl)-2H-indazol-5-ol
2H-Indazol-5-ol, 3-chloro-2-(4-hydroxyphenyl)- | [Molecular Formula]
C13H9ClN2O2 | [MDL Number]
MFCD23704786 | [MOL File]
848142-62-1.mol | [Molecular Weight]
260.68 |
| Hazard Information | Back Directory | [Uses]
Indazole-Cl (Ind-Cl) is an Estrogen receptor (ER)-β-specific agonist with inflammatory effect. Indazole-Cl inhibits cyclooxygenase-2 exression reduction induced by hypoxia. And Indazole-Cl inhibits ROS production. Indazole-Cl also inhibits cell migration and invasion by hypoxia increased by hypoxia. Indazole-Cl is potent inhibitor of hypoxia-induced in?ammation in vascular smooth muscle cells (VSMCs)[1]. | [IC 50]
COX-2 | [References]
[1] Park C, et al. Indazole-Cl inhibits hypoxia-induced cyclooxygenase-2 expression in vascular smooth muscle cells. J Mol Endocrinol. 2019 Jul 1;63(1):27-38. DOI:10.1530/JME-19-0018 |
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