| Identification | Back Directory | [Name]
EX-527 (R-enantioMer) | [CAS]
848193-69-1 | [Synonyms]
EX-527(R‰
(R)-Selisistat
EX-527 (R-enantioMer)
(R)-SELISISTAT; EX-527(R); EX 527(R); EX527(R);
(R)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | [Molecular Formula]
C13H13ClN2O | [MDL Number]
MFCD28291828 | [MOL File]
848193-69-1.mol | [Molecular Weight]
248.71 |
| Chemical Properties | Back Directory | [Boiling point ]
531.7±38.0 °C(Predicted) | [density ]
1.388±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Powder | [pka]
16.12±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
(R)-Selisistat ((R)-EX-527) is a R-enantiomer of Selisistat. Selisistat (EX-527) is a potent and selective SIRT1 inhibitor with IC50 of 98 nM. | [Definition]
ChEBI: (R)-selisistat is a 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide that has R configuration. It is the inactive enantiomer. It is an enantiomer of a (S)-selisistat. | [References]
[1] Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54. DOI:10.1021/jm050522v |
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