| Identification | Back Directory | [Name]
8-chloro-2-methyl-4-(4-methylpiperazin-1-yl)-[1]benzofuro[3,2-d]pyrimidine | [CAS]
848217-00-5 | [Synonyms]
H4 Receptor antagonist 1
Benzofuro[3,2-d]pyrimidine, 8-chloro-2-methyl-4-(4-methyl-1-piperazinyl)-
8-chloro-2-methyl-4-(4-methylpiperazin-1-yl)-[1]benzofuro[3,2-d]pyrimidine | [Molecular Formula]
C16H17ClN4O | [MDL Number]
MFCD04189244 | [MOL File]
848217-00-5.mol | [Molecular Weight]
316.79 |
| Chemical Properties | Back Directory | [density ]
1.328±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 10 mg/mL (31.57 mM) | [form ]
Solid | [pka]
6.73±0.42(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist, with an IC50 of 19 nM. | [in vivo]
H4 Receptor antagonist 1 indicates that metabolic stability in rat microsomes is very low with only 1% parent compound remaining after 10 min incubation[1]. | [IC 50]
H4 receptor: 19 nM (IC50) | [References]
[1] Cramp S, et al. Identification and hit-to-lead exploration of a novel series of histamine H4 receptor inverse agonists. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2516-9. DOI:10.1016/j.bmcl.2010.02.097 |
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