| Identification | Back Directory | [Name]
Lascufloxacin | [CAS]
848416-07-9 | [Synonyms]
KRP-AM1977
KRP-AM1977X
Lascufloxacin
3-Quinolinecarboxylic acid, 7-[(3S,4S)-3-[(cyclopropylamino)methyl]-4-fluoro-1-pyrrolidinyl]-6-fluoro-1-(2-fluoroethyl)-1,4-dihydro-8-methoxy-4-oxo- | [Molecular Formula]
C21H24F3N3O4 | [MDL Number]
MFCD28963970 | [MOL File]
848416-07-9.mol | [Molecular Weight]
439.43 |
| Chemical Properties | Back Directory | [Boiling point ]
637.0±55.0 °C(Predicted) | [density ]
1.44±0.1 g/cm3(Predicted) | [solubility ]
Chloroform (Slightly), DMSO (Very Slightly) | [form ]
Solid | [pka]
6.29±0.50(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Uses]
Lascufloxacin is an intermediate used in the preparation of quinolonecarboxylic acid deriatives as antibacterial agents. | [in vivo]
A pharmacodynamic study using a mouse thigh infection model indicates that the ratios of the free area under the curve (fAUC) to MIC in plasma required for bacteriostasis, or 1-log or 2-log CFU killing against S. pneumoniae isolates, are 10, 16, and 28, respectively. Lascufloxacin shows significant bacterial killing in the mouse model when emulated the area under the concentration-time curve (AUC) in plasma in dose of 75 mg per day [q.d.]) [2]. | [IC 50]
Quinolone |
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| Company Name: |
Moltt Biocem Co., Ltd.
|
| Telephone: |
+86-21-38682181 15900741819 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15856/0_EN.htm |
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