| Identification | Back Directory | [Name]
L-Tryptophan, N-[[1-[[(2S)-2-Mercapto-4-Methyl-1-oxopentyl]aMino]cyclopentyl]carbonyl]- | [CAS]
849066-09-7 | [Synonyms]
CGS 35601
YFAHICISBQLBQH-OALUTQOASA-N
L-Tryptophan, N-[[1-[[(2S)-2-Mercapto-4-Methyl-1-oxopentyl]aMino]cyclopentyl]carbonyl]- | [Molecular Formula]
C23H31N3O4S | [MDL Number]
MFCD25977043 | [MOL File]
849066-09-7.mol | [Molecular Weight]
445.575 |
| Hazard Information | Back Directory | [Uses]
CGS 35601 is the inhibitor for endothelin-converting enzyme-1 (ECE-1), neutral endopeptidase 24.11 (NEP), and angiotensin-converting enzyme (ACE), with IC50s of 55, 2, and 22 nM, respectively. CGS 35601 suppresses the big endothelin-1 (big ET-1)- and angiotensin I-induced pressor response, and enhances circulation of atrial natriuretic peptide (ANP), regulates the cardiovascular function in SD rats[1]. | [References]
[1] Trapani AJ, et al., CGS 35601 and its orally active prodrug CGS 37808 as triple inhibitors of endothelin-converting enzyme-1, neutral endopeptidase 24.11, and angiotensin-converting enzyme. J Cardiovasc Pharmacol. 2004 Nov;44 Suppl 1:S211-5. DOI:10.1097/01.fjc.0000166237.57077.d6 |
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