| Identification | Back Directory | [Name]
TPI-287 | [CAS]
849213-15-6 | [Synonyms]
TPI-287
Hexanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-5-methyl-, (1S,2S,4S,7S,7aR,10aS,11aR,13aS,13bR,13cS)-7,13a-bis(acetyloxy)-1-(benzoyloxy)-9-ethenyl-1,3,4,7,7a,10a,11,11a,13,13a,13b,13c-dodecahydro-2-hydroxy-5,13c,14,14-tetramethyl-2,6-methano-2H-cyclodec[de]oxeto[3,2-g][1,3]benzodio...
(2R,3S)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-hydroxy-5-methyl-hexanoic acid (1S,2S,4S,7S,7aR,10aS,11aR,13aS,13bR,13cS)-7,13a-bis(acetyloxy)-1-(benzoyloxy)-9-ethenyl-1,3,4,7,7a,10a,11,11a,13,13a,13b,13c-dodecahydro-2-hydroxy-5,13c,14,14-tetramethyl-2,6-methano-2H-cyclodec[de]oxeto[3,2-g][1,3]benzodioxin-4-yl ester | [Molecular Formula]
C46H63NO15 | [MOL File]
849213-15-6.mol | [Molecular Weight]
870 |
| Chemical Properties | Back Directory | [Boiling point ]
857.4±65.0 °C(Predicted) | [density ]
1.29±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
11.75±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
TPI-287, a blood-brain barrier-permeable microtubule stabilizer, can significantly reduce metastatic colonization of breast cancer in the brain[1]. | [in vivo]
TPI-287(i.v., 18 mg/kg, every 4 days, 41 days) can effectively reduce tumor volume and inhibit tumor growth in mouse tumor models inoculated with 231-BR breast cancer cells[1].
| [References]
[1] Daniel P Fitzgerald, et al. TPI-287, a new taxane family member, reduces the brain metastatic colonization of breast cancer cells. Mol Cancer Ther. 2012 Sep;11(9):1959-67. DOI:10.1158/1535-7163.MCT-12-0061 |
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