| Identification | Back Directory | [Name]
c-GpAp | [CAS]
849214-04-6 | [Synonyms]
cGAMP
c-GpAp
di-GAMP
di-cGAMP
3'3'-cGAMP
Cyclic GMP-AMP
cGAMP ammonium salt
cGAMP (Cyclic GMP-AMP
c-(ApGp) / 3'3'-cGAMP
RFCBNSCSPXMEBK-XRIIRFCZSA-N
3''-Guanylic acid, adenylyl-(3''?5'')-, cyclic nucleotide
3',3'-Cyclic guanosine monophosphate-adenosine monophosphate | [Molecular Formula]
C20H24N10O13P2 | [MDL Number]
MFCD28411367 | [MOL File]
849214-04-6.mol | [Molecular Weight]
674.41 |
| Chemical Properties | Back Directory | [Boiling point ]
1159.9±75.0 °C(Predicted) | [density ]
2.61±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [form ]
powder | [pka]
0.96±0.70(Predicted) | [color ]
white to beige | [Water Solubility ]
Water : 20 mg/mL (29.66 mM) |
| Hazard Information | Back Directory | [Uses]
c-GpAp induces the production of interferons, a usual response to triggers in the cytoplasm of mammalian cells by the presence of DNA. | [Definition]
ChEBI: C-GMP-AMP is a cyclic purine dinucleotide that consists of AMP and GMP units cyclised via 3',5'-linkages. It is an adenyl ribonucleotide, a cyclic purine dinucleotide and a guanyl ribonucleotide. It is a conjugate acid of a c-GMP-AMP(2-). | [Biochem/physiol Actions]
cGAMP induces the formation of cytokines (interferon-β, interferon-γ), activation of dendritic cells and CD8+ T cell cross priming. Through this action, it promotes innate immune response. cGAMP possesses antitumor activity and is prefered for immunotherapy in cancer treatment. | [in vivo]
cGAMP promotes the antigen-specific cytokine production by spleen cells of immunized mice[2].
| Animal Model: | Female C57BL/6 (H-2b) mice 6–8 weeks old[2] | | Dosage: | 5 μg | | Administration: | Nostril mucosal adjuvant | | Result: | Higher titers of ovalbumin (OVA)-specific IgA and total IgG as well as IgG1 and IgG2c in the sera of mice immunized with cGAMP-adjuvanted OVA as compared to sera from OVA-immunized mice. |
| [storage]
Store at -20°C |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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