ChemicalBook--->CAS DataBase List--->849550-67-0

849550-67-0

849550-67-0 Structure

849550-67-0 Structure
IdentificationBack Directory
[Name]

Cevipabulin fumarate
[CAS]

849550-67-0
[Synonyms]

TTI-237 fumarate
[Molecular Formula]

C22H22ClF5N6O5
[MOL File]

849550-67-0.mol
[Molecular Weight]

580.9
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 50 mg/mL (86.07 mM)
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Cevipabulin fumarate (TTI-237 fumarate) is an oral, microtubule-active, antitumor compound and inhibits the binding of [3H]NSC 49842 to tubulin, with an IC50 of 18-40 nM for cytotoxicity in human tumor cell line[1][2].
[in vivo]

Cevipabulin (TTI-2370)( 5, 10, 15, and 20 mg/kg, every 4 days for 4 cycles, in mice) is active by i.v. and p.o. administration against human tumor xenografts, showing dose-dependent effects, with good antitumor activity at 20 and 15 mg/kg[1].

Animal Model:Athymic nu/nu female mice implanted s.c. in the flank with 1×107 LoVo human colon adenocarcinoma cells[1].
Dosage:5, 10, 15, and 20 mg/kg
Administration:I.V. injection every 4 days for 4 cycles.
Result:The compound showed dose-dependent effects, with good antitumor activity at 20 and 15 mg/kg.
Animal Model:Athymic nu/nu female mice implanted s.c. in the flank with 1×106 U87-MG human glioblastoma cells[1].
Dosage:25 mg/kg.
Administration:P.O. or I.V. on days 0, 7, 14.
Result:The compound was active by p.o. or i.v. administration against human tumor xenografts.
[storage]

Store at -20°C
[References]

[1] Beyer CF, et al. TTI-237: a novel microtubule-active compound with in vivo antitumor activity. Cancer Res. 2008 Apr 1;68(7):2292-300. DOI:10.1158/0008-5472.CAN-07-1420
[2] Beyer CF, et al. The microtubule-active antitumor compound TTI-237 has both DB01229-like and Leurocristine-like properties. Cancer Chemother Pharmacol. 2009 Sep;64(4):681-9. DOI:10.1007/s00280-008-0916-2
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849550-69-2 849550-05-6

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