| Identification | Back Directory | [Name]
5-BROMO-2,4-DICHLORO-PYRIDINE | [CAS]
849937-96-8 | [Synonyms]
2,4-dichloro-5-bromopyridine
Pyridine, 5-bromo-2,4-dichloro-
5-BROMO-2,4-DICHLORO-PYRIDINE ISO 9001：2015 REACH
5-Bromo-2,4-dichloropyridine5-Bromo-2,4-dichloropyridine | [EINECS(EC#)]
214-589-6 | [Molecular Formula]
C5H2BrCl2N | [MDL Number]
MFCD09031035 | [MOL File]
849937-96-8.mol | [Molecular Weight]
226.89 |
| Chemical Properties | Back Directory | [Melting point ]
21-22℃ | [Boiling point ]
60-62℃ (0.9 Torr) | [density ]
1.848±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [form ]
liquid | [pka]
-1.31±0.10(Predicted) | [color ]
Yellow | [InChI]
InChI=1S/C5H2BrCl2N/c6-3-2-9-5(8)1-4(3)7/h1-2H | [InChIKey]
SGCSNJNPPSSPKZ-UHFFFAOYSA-N | [SMILES]
C1(Cl)=NC=C(Br)C(Cl)=C1 |
| Questions And Answer | Back Directory | [Uses]
2,4-Dichloro-5-bromopyridine is an important biopharmaceutical intermediate widely used in the synthesis of various drugs. Its small molecular weight and unique structure allow for the derivation of numerous downstream products, giving it a wide range of applications. |
| Hazard Information | Back Directory | [Synthesis]
5-bromo-2-chloropyridine could be used as a starting material to synthesize 5-Bromo-2,4-dichloropyridine. At -100 °C, diisopropylamine (14 mL, 10 g, 0.10 mol) and 5-bromo-2-chloropyridine (19 g, 0.10 mol) were added consecutively to a solution of butyllithium (0.10 mol) in tetrahydrofuran (0.23 L) and hexanes (60 mL). After 45 min at -100 °C, the mixture was treated with 1,1,2-trichloro-1,2,2-trifluoroethane (12 mL, 19 g, 0.10 mol) and, after 45 min at -75 °C, with water (50 mL). Upon distillation, the product was collected as a colorless liquid, bp 60-62 °C/0.9 mmHg, yield 18.7 g (83%). |
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