| Identification | Back Directory | [Name]
N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]biphenyl-4-carboxamide | [CAS]
850467-66-2 | [Synonyms]
CP 43
TAOK inhibitor 43
N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]-4-phenylbenzamide
N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]biphenyl-4-carboxamide
N-[2-Oxo-2-(1,2,3,4-tetrahydro-1-naphthalenylamino)ethyl]-4-biphenylcarboxamide
N-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide
[1,1'-Biphenyl]-4-carboxamide, N-[2-oxo-2-[(1,2,3,4-tetrahydro-1-naphthalenyl)amino]ethyl]- | [Molecular Formula]
C25H24N2O2 | [MDL Number]
MFCD15612807 | [MOL File]
850467-66-2.mol | [Molecular Weight]
384.47 |
| Chemical Properties | Back Directory | [Boiling point ]
673.2±54.0 °C(Predicted) | [density ]
1.22±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 100 mM; Ethanol: 20 mM | [form ]
A solid | [pka]
13.08±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Compound 43 TAO kinase inhibitor is an ATP-competitive inhibitor of the thousand-and-one amino acid kinases TAOK1 and TAOK2 (IC50s = 11 and 15 nM, respectively). It is selective for TAOK1 and TAOK2 over 62 kinases in a panel, but does inhibit TAOK3 by 87% and seven additional kinases by 21-52%. Compound 43 TAO kinase inhibitor inhibits proliferation of SK-BR-3, BT-549, and MCF-7 cells by 94, 82, and 46%, respectively, at a concentration of 10 μM. It reduces tau phosphorylation by TAOK2 at residues S262/S356 and S202/T205/S208 when used at concentrations ranging from 5 to 60 μM in a kinase assay and at residues S202/T205/S208 when used at concentrations of 5, 10, and 30 μM in HEK293 cells. Compound 43 TAO kinase inhibitor reduces tau phosphorylation of residues T123 and T427, which are phosphorylated by TAOK1 and TAOK2 in vitro and have been identified in tangles in Alzheimer’s disease brain tissue. It also reduces tau phosphorylation in cortical neurons in a transgenic mouse model of tauopathy and in induced pluripotent stem cell-derived neurons from patients with frontotemporal lobar degeneration. | [Uses]
CP 43 is a potent TAO kinase (TAOK) inhibitor (IC50 values are 11 nM/L and 15 nM/L for TAOK1 and TAOK2, respectively). Inhibits TAOK phosphorylation and activation of JNK in vitro. Also prolongs duration of mitosis and increases mitotic cell death in the SKBR3 breast cancer cell line. | [storage]
Store at RT | [References]
[1] CHUAY-YENG KOO. Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells.[J]. Molecular Cancer Therapeutics, 2017, 16 11: 2410-2421. DOI: 10.1158/1535-7163.mct-17-0077
[2] CATERINA GIACOMINI. A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies.[J]. Acta Neuropathologica Communications, 2018: 37. DOI: 10.1186/s40478-018-0539-8 |
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| Company Name: |
Struchem Co., Ltd.
|
| Telephone: |
0512-63009836 18994340901 |
| Website: |
http://www.beidapharma.com |
| Company Name: |
Bide Pharmatech Ltd.
|
| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
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