| Identification | Back Directory | [Name]
N-(4-HYDROXYPHENYL)-5-METHYL-2-1H-PYRIDONE | [CAS]
851518-71-3 | [Synonyms]
F 351
Voxtalisib Hydrochloride
N-(4-HYDROXYPHENYL)-5-METHYL-2-1H-PYRIDONE
1-(4-Hydroxyphenyl)-5-Methyl-2(1H)-pyridinone
1-(4-Hydroxyphenyl)-5-Methylpyridin-2(1H)-one | [Molecular Formula]
C12H11NO2 | [MDL Number]
MFCD07369446 | [MOL File]
851518-71-3.mol | [Molecular Weight]
201.22 |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
161-162°C | [Boiling point ]
416.0±37.0 °C(Predicted) | [density ]
1.248±0.06 g/cm3(Predicted) | [storage temp. ]
-20?C Freezer | [solubility ]
Chloroform (Slightly), Methanol | [form ]
Solid | [pka]
10.08±0.30(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
A metabolite of Pirfenidone, a new drug to treat patients with kidney disease who have diabetes | [in vivo]
Hydronidone (50-100 mg/kg; p.o.) ameliorates CCl4-induced and DDC-induced liver fibrosis and hepatic injury in mice[1].
Hydronidone significantly promotes apoptosis in activated hepatic stellate cells (aHSCs) in the CCl4- and DDC-induced liver fibrosis in mice[2].
| Animal Model: | Five-week-old male C57BL/6J mice (intraperitoneally injected with 10% carbon tetrachloride (CCl4) in corn oil at 5?μL/g of body weight, three times per week, for 6?weeks; or fed a diet containing 1% 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) for 4?weeks)[1] | | Dosage: | 50, 100 mg/kg | | Administration: | Oral gavage (p.o.) | | Result: | The levels of hepatic inflammatory infiltration were improved.
Significantly reduced the collagen fibre content.
Decreased the hepatic hydroxyproline content.
Significantly reduced the mRNA levels of fibrosis-related genes, including Acta2, Col1a1, Col3a1, Mmp9 and Timp1.
Reduced the levels of α-SMA and collagen 1 (Col1) in liver tissues.
Upregulated Smad7 protein expression.
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