| Identification | Back Directory | [Name]
PIAA | [CAS]
851814-28-3 | [Synonyms]
PIAA
2-Propenoic acid, 3-(3-phenyl-2,1-benzisoxazol-5-yl)- | [Molecular Formula]
C16H11NO3 | [MDL Number]
MFCD06386715 | [MOL File]
851814-28-3.mol | [Molecular Weight]
265.26 |
| Chemical Properties | Back Directory | [Boiling point ]
511.9±35.0 °C(Predicted) | [density ]
1.323±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear (warmed) | [form ]
powder | [pka]
4.08±0.50(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Definition]
ChEBI: 3-(3-phenyl-2,1-benzoxazol-5-yl)-2-propenoic acid is a member of cinnamic acids. | [Biological Activity]
PIAA is an inhibitor of TANK binding kinase 1 (TBK1) and IKB kinase epsilon (IKKε) th at has been shown to promote regeneration of pancreatic β-cells. PIAA improved function and replication of mammalian β-cells including primary human β-cells and induced β-cell proliferation in streptozotocin-induced diabetic mice resulting in increased pancreas insulin content and improved glycemic control. PIAA exhibited an IC50 value of 400 nM for TBK1 and 1.07 μM for IKKε with minimum toxicity |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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