851956-01-9

88495-54-9

851956-01-9

The general steps for the synthesis of (S)-piperidine-3-carboxylic acid hydrochloride from N-Boc-(S)-3-carboxylic acid piperidine are as follows: Step 1. Preparation of (3S)-piperidine-3-carboxylic acid hydrochloride (3S)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid (4.0 g, 0.017 mol) was dissolved in dichloromethane (10 mL, 0.2 mol), and a 1,4-dioxane solution (30 mL) of 4.0 M hydrogen chloride was added. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the volatiles were removed by vacuum distillation to give (3S)-piperidine-3-carboxylic acid hydrochloride in quantitative yield. The crude product did not require further purification and could be used directly in subsequent steps.LCMS analysis showed m/z 166.2 (M + H)+.