| Identification | Back Directory | [Name]
Dutogliptin | [CAS]
852329-66-9 | [Synonyms]
Dutogliptin
PHX-1149 free base
((R)-1-(((R)-pyrrolidin-3-yl)glycyl)pyrrolidin-2-yl)boronic acid
[(2R)-1-[[(3R)-3-Pyrrolidinylamino]acetyl]-2-pyrrolidinyl]-boronic acid
Boronic acid, B-[(2R)-1-[2-[(3R)-3-pyrrolidinylamino]acetyl]-2-pyrrolidinyl]- | [Molecular Formula]
C10H20BN3O3 | [MDL Number]
MFCD16038042 | [MOL File]
852329-66-9.mol | [Molecular Weight]
241.1 |
| Chemical Properties | Back Directory | [Boiling point ]
494.6±55.0 °C(Predicted) | [density ]
1.24±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 300 mg/mL (1244.30 mM) | [form ]
Solid | [pka]
9.71±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Dutogliptin (PHX-1149 free base) is an orally available, potent, and selective dipeptidyl peptidase-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus. | [in vivo]
Dutogliptin exhibits low plasma protein binding (11%) and is rapidly absorbed with a Tmax of 3-4 h and a half-life of 10-13 h. Dutogliptin is metabolically stable and does not inhibit or induce the activity of major CYP450s[2]. | [storage]
Store at -20°C | [References]
[1] Marier JF, et al. Population pharmacokinetic analysis of dutogliptin, a selective dipeptidyl peptidase-4 inhibitor. Clin Pharmacol Drug Dev. 2014 Jul;3(4):297-304. DOI:10.1002/cpdd.87
[2] Pattzi HM, et al. Dutogliptin, a selective DPP4 inhibitor, improves glycaemic control in patients with type 2 diabetes: a 12-week, double-blind, randomized, placebo-controlled, multicentre trial. Diabetes Obes Metab. 2010 Apr;12(4):348-55. DOI:10.1111/j.1463-1326.2010.01195.x |
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