| Identification | Back Directory | [Name]
2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- | [CAS]
852391-19-6 | [Synonyms]
Necrostatin 2
Necroptotic Inhibitor
Necrostatin 2 R-isomer
MTH-DL-TRYPTOPHAN; NECROPTOTIC INHIBITOR
(5R)-5-[(7-Chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione
2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- | [Molecular Formula]
C13H12ClN3O2 | [MOL File]
852391-19-6.mol | [Molecular Weight]
277.71 |
| Chemical Properties | Back Directory | [density ]
1.450±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
crystalline solid | [pka]
8.48±0.70(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
Necrostatin 2 is a potent necroptosis inhibitor. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM. Necrostatin 2 is also a RIPK1 inhibitor. | [Biological Activity]
necrostatin 2 (nec-2) is a novel and potent necroptosis inhibitor with ec50 of 50 nm. it is an analog of necrostatin 1 (nec-1).necroptosis is a mechanism of necrotic cell death induced by apoptotic stimuli in the form of death domain receptor engagement by their respective ligands under conditions where apoptotic execution is prevented.nec-2 is efficacious in an animal model of ischemic stroke. many necroptosis inhibitor derivatives are designed for researchers. there is limited record for nec-2, but some reports are related with other necrostatins. nec-1, a small-molecule inhibitor of necroptosis, is also a selective allosteric inhibitor of the death domain receptor-associated adaptor kinase rip1 in vitro. | [target]
RIPK2 | [IC 50]
RIPK1 | [References]
[1]. teng x, keys h, jeevanandam a, structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. bioorg med chem lett. 2007 dec 15;17(24):6836-40. |
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