| Identification | Back Directory | [Name]
5-BROMOISOQUINOLIN-1-AMINE | [CAS]
852570-80-0 | [Synonyms]
5-BROMOISOQUINOLIN-1-AMINE
5-Bromo-1-isoquinolinamine
1-Amino-5-bromoisoquinoline
5-bromoisoquinolin-1-ylamine
1-Isoquinolinamine, 5-bromo-
1-Amino-5-bromoisoquinoline 95%
5-BROMOISOQUINOLIN-1-AMINE ISO 9001：2015 REACH
5-Bromoisoquinolin-1-amine, 1-Amino-5-bromo-2-azanaphthalene | [Molecular Formula]
C9H7BrN2 | [MDL Number]
MFCD11226920 | [MOL File]
852570-80-0.mol | [Molecular Weight]
223.07 |
| Chemical Properties | Back Directory | [Boiling point ]
380.7±27.0 °C(Predicted) | [density ]
1.649 | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [form ]
solid | [pka]
6.50±0.43(Predicted) | [color ]
White to faint orange |
| Hazard Information | Back Directory | [Synthesis]
Step 3: To a 500 mL round bottom flask purged with nitrogen and maintained in an inert atmosphere under nitrogen protection was added a mixture of 5-bromo-1-chloroisoquinoline (17.5 g, 72.16 mmol, 1.00 eq.), AcNH2 (85.8 g, 1.45 mol, 20.15 eq.) and potassium carbonate (49.0 g, 354.53 mmol, 4.91 equivalent) in a mixture. The reaction mixture was stirred at 180 °C for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and slowly poured into 2000 mL of water with stirring. The precipitated solid was collected by filtration to give 12.0 g (75% yield) of 5-bromoisoquinolin-1-amine as a brown solid. | [References]
[1] Patent: WO2005/49576, 2005, A1. Location in patent: Page/Page column 29
[2] Patent: WO2005/49577, 2005, A1. Location in patent: Page/Page column 32-33
[3] Patent: WO2016/201052, 2016, A1. Location in patent: Page/Page column 272
[4] Patent: WO2008/86014, 2008, A2. Location in patent: Page/Page column 60 |
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ZEROSCHEM.CO.,LTD.
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http://www.zeroschem.com |
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