| Identification | Back Directory | [Name]
(D-THR2)-LEUCINE ENKEPHALIN-THR ACETATE | [CAS]
85286-38-0 | [Synonyms]
Enkephalin leu
thr(2)-thr(6)-
DTLET, Deltakephalin
[D-Thr2,Leu5]enkephalin-Thr
Enkephalin leu, thr(2)-thr(6)-
(D-THR2)-LEUCINE ENKEPHALIN-THR ACETATE
(D-THREONINE2)-LEUCINE ENKEPHALIN-THREONINE ACETATE)
(D-Thr2)-Leu-Enkephalin-Thr H-Tyr-D-Thr-Gly-Phe-Leu-Thr-OH
L-Threonine, L-tyrosyl-D-threonylglycyl-L-phenylalanyl-L-leucyl- | [Molecular Formula]
C34H48N6O10 | [MDL Number]
MFCD00079927 | [MOL File]
85286-38-0.mol | [Molecular Weight]
700.785 |
| Hazard Information | Back Directory | [Uses]
Deltakephalin is a potent, selective opiate δ-receptor agonist. Deltakephalin has analgesic properties[1]. | [in vivo]
Deltakephalin (2 nM/rat; ICV; once) produces a pronounced analgesia in rats[1]. | Animal Model: | Male spontaneously hypertensive rats (SHR/n/Ibm) and male Wistar Albino Glaxo rats (WAG) (250-300 g)[1] | | Dosage: | 2 nM/rat | | Administration: | Intracerebroventrical injection | | Result: | Produced pronounced analgesia in male spontaneously hypertensive rats with EC50 values of 0.57 and 0.88 nM for the tail flick test and the tail compression test, respectively. |
| [References]
[1] Widy-Tyszkiewicz E, et, al. Analgesic activity of morphiceptin, beta-casomorphin-4, and deltakephalin in normotensive Wistar-Glaxo and spontaneously hypertensive rats. Peptides. 1989 May-Jun;10(3):539-44. DOI:10.1016/0196-9781(89)90139-3 |
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